Detalhe da pesquisa
1.
Effect of capmatinib on the pharmacokinetics of substrates of CYP3A (midazolam) and CYP1A2 (caffeine) in patients with MET-dysregulated solid tumours.
Br J Clin Pharmacol
; 89(3): 1046-1055, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36131603
2.
Pharmacokinetics of capmatinib in participants with hepatic impairment: A phase 1, open-label, single-dose, parallel-group study.
Br J Clin Pharmacol
; 88(1): 91-102, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34046915
3.
Clinical Investigation of Metabolic and Renal Clearance Pathways Contributing to the Elimination of Fevipiprant Using Probenecid as Perpetrator.
Drug Metab Dispos
; 49(5): 389-394, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33632715
4.
Effect of capmatinib on the pharmacokinetics of digoxin and rosuvastatin administered as a 2-drug cocktail in patients with MET-dysregulated advanced solid tumours: A phase I, multicentre, open-label, single-sequence drug-drug interaction study.
Br J Clin Pharmacol
; 87(7): 2867-2878, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33300203
5.
Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite.
Drug Metab Dispos
; 48(10): 873-885, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32665418
6.
Fevipiprant (QAW039) does not affect the pharmacokinetics of zidovudine, its glucuronide, and penicillin G via inhibition of UGT2B7 and/or OAT3.
Pulm Pharmacol Ther
; 72: 102097, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34800680
7.
Midostaurin drug interaction profile: a comprehensive assessment of CYP3A, CYP2B6, and CYP2C8 drug substrates, and oral contraceptives in healthy participants.
Cancer Chemother Pharmacol
; 93(5): 439-453, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38270613
8.
Evaluation of the Pharmacokinetic Drug Interaction of Capmatinib With Itraconazole and Rifampicin and Potential Impact on Renal Transporters in Healthy Subjects.
J Clin Pharmacol
; 63(2): 228-238, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36087217
9.
Correction to: Midostaurin drug interaction profile: a comprehensive assessment of CYP3A, CYP2B6, and CYP2C8 drug substrates, and oral contraceptives in healthy participants.
Cancer Chemother Pharmacol
; 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38438807
10.
Endocrine and behavioural responses to acute central CRF challenge are antagonized in the periphery and CNS, respectively, in C57BL/6 mice.
Neuropharmacology
; 60(2-3): 318-27, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-20868699